Features of the development of an adaptive antiviral immune response

Both well-known basic cellular and humoral factors of the adaptive antiviral immune response, which play an important role in effectiveness immunological reactions to inhibit viral infections, new with efficiency functioning mechanisms a specific response is associated are considered. This is, first all, presence naive T-lymphocytes macroorganism, programmed recognize antigen. In addition, this facilitated by various receptor specificities T-lymphocytes, there more than 20 million. The diversity structures was believed be genes that activate recombinase. development cell-mediated depends on interleukins 12, interferon-, transcriptional activator T-bet. An imbalance ratio T-helper cell types 1 2 can lead memory damage. Th-17 plays central controlling infection. balance between activated cytotoxic CD-8+/T-helper cells T-regulatory lymphocytes determines risk immunopathology. excess effector leads immune-mediated damage, lack chronicity One ensure minimal damage tissues assembly cytoplasmic protein complex antigen-presenting cellsinflammasomes. intensity inflammatory processes whether virus cytopathic. also attributed fact one plasma secrete 2,000 antibody molecules per second. powerful properties different T cells. To date, at least three subpopulations activation requirements have been identified. Thus, determining how each these contributes long-term protection macroorganism urgent task.